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Table 9 The small company perspective and the impact of geopolitical changes and the risk of not being able to access large trading blocks, on values. (values indicated in $mn, using the latest success rates)

From: A novel valuation model for medical intervention development based on progressive dynamic changes that integrates Health Technology Assessment outcomes with early-stage innovation and indication-specific clinical success rates

 100% market penetrance40% market penetrance
IRR
 rNPV post Ph Inegativenegative
 rNPV post Ph IInegativenegative
 rNPV post Ph III4.143.25
pd-DRR
 rNPV post Ph Inegativenegative
 rNPV post Ph IInegativenegative
 rNPV post Ph III0.960.73