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A Systems View Across Time and Space

Table 2 Real-world SOM calculations for hypertension based on 2017 top ten UK drug prescriptions for hypertension

From: A novel valuation model for medical intervention development based on progressive dynamic changes that integrates Health Technology Assessment outcomes with early-stage innovation and indication-specific clinical success rates

Name

Number of pills sold

% market share of top ten (SOM)

Ramipril

27,918,000

40.47

Lisinopril

9,087,000

13.17

Losartan potassium

9,447,000

13.70

Candesartan Cilexetil

6,738,000

9.77

Doxazosin Mesilate

6,519,000

9.45

Perindopril Erbumine

4,701,000

6.81

Irbesartan

1,911,000

2.77

Enalapril Maleate

1,756,000

2.55

Olmesartan Medoxomil

474,000

0.69

Moxonidine

430,000

0.62

Total

68,981,000

100

  1. The sales of the top ten leading antihypertension drugs in the UK were obtained from Statista, and then converted into real-world serviceable obtainable market (SOM) percentages to generate market penetrance values for future simulations